About Amlodipine Calcium Channel Blocker, Anti hypertensive,anti angina. Mechanism of Action of Amlodipine Amlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion. Indications for Amlodipine 1.Hypertension 2.Prinzmetal`s angina 3.Stable angina